n-3 PUFA can inhibit the apoptosis of intestinal epithelial cells of chronic rejection after small intestinal transplantation / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6): 355-357,363, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-597802
ABSTRACT
Objective:
The aim of our work was to investigate the effects of n-3 polyunsaturated fatty acids on apoptosis, granzyme B and perforin expression of intestinal epithelial cells of chronic rejection after small intestinal transplantation.Methods:
Small bowel transplantation was performed and rats were divided into three groups Group 1, Lewis-to-Lewis, group 2, F344-to-Lewis, dietary corn oil, Group 3, F344-to-Lewis, dietary fish oil. All recipients were killed after 16 weeks of posttransplantation. The apoptosis rate of mucosal cells were evaluated by flow cytometry. The expressions of granzyme B and perforin were analyzed by reverse transcriptase RT-PCR.Results:
A high apoptotic rate was observed when the allografts demonstrated one or more histological features of chronic rejection. N-3 polyunsaturated fatty acids decreased the rate of the apoptosis and inhibitted the expressions of granzyme B and perforin.Conclusion:
N-3 polyunsaturated fatty acids can suppress the chronic rejection in small intestinal transplantation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Parenteral & Enteral Nutrition
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS