Comparison of palonosetron with ondansetron in prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after gynecological laparoscopic surgery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 122-126, 2013.
Article
in English
| WPRIM
| ID: wpr-59812
ABSTRACT
BACKGROUND:
Postoperative nausea and vomiting (PONV) are common complications after anesthesia and surgery. This study was designed to compare the effects of palonosetron and ondansetron in preventing PONV in high-risk patients receiving intravenous opioid-based patient-controlled analgesia (IV-PCA) after gynecological laparoscopic surgery.METHODS:
One hundred non-smoking female patients scheduled for gynecological laparoscopic surgery were randomly assigned into the palonosetron group (n = 50) or the ondansetron group (n = 50). Palonosetron 0.075 mg was injected as a bolus in the palonosetron group. Ondansetron 8 mg was injected as a bolus and 16 mg was added to the IV-PCA in the ondansetron group. The incidences of nausea, vomiting and side effects was recorded at 2 h, 24 h, 48 h and 72 h, postoperatively.RESULTS:
There were no significant differences between the groups in the incidence of PONV during 72 h after operation. However, the incidence of vomiting was lower in the palonosetron group than in the ondansetron group (18% vs. 4%, P = 0.025). No differences were observed in use of antiemetics and the side effects between the groups.CONCLUSIONS:
The effects of palonosetron and ondansetron in preventing PONV were similar in high-risk patients undergoing gynecological laparoscopic surgery and receiving opioid-based IV-PCA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinuclidines
/
Vomiting
/
Incidence
/
Analgesia, Patient-Controlled
/
Ondansetron
/
Laparoscopy
/
Postoperative Nausea and Vomiting
/
Anesthesia
/
Isoquinolines
/
Antiemetics
Type of study:
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS