Clinical research on central nerve system infiltration in patients with diffuse large B-cell lymphoma / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 113-114,118, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-598210
ABSTRACT
Objective To evaluate the morbidity,clinical manifestation,risk factors and prognosis of diffuse large B-cell lymphoma(DLBCL)patients with central nerve system(CNS)infiltration.Methods Clinical data of DLBCL patients with CNS infiltration between Jan 2005 and Jan 2012 were reviewed.Results Among 168 DLBCL patients,11 patients(6.5 %)had CNS infiltration.ECOG scores ≥ 2,elevated lactate dehydrogenase(LDH)> 2 times of normal range and the involvement of ≥ 2 extranodal sites were clinical risk factors associated with CNS inflitration(x2 =11.6,4.61,3.92,all P < 0.005).Median survival time after CNS infiltration was 4.5 months.Conclusion DLBCL patients with CNS infiltration are not rare,the patients demonstrate significantly bad prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Risk factors
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS