Protective effects of L-carnitine on newborn with hypoxic ischemic myocardial injury / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
;
(12): 52-54,61, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-598213
ABSTRACT
Objective To explore the effects of L-carnitine on newborn with hypoxic ischemic myocardial injury.Methods Sixty cases with hypoxic ischemic myocardial injury were divided into two groups,including control group (n =30) receiving fructose sodium diphosphate injection,and experimental group (n =30) receiving both fructose sodium diphosphate and L-carnitine injection for 7 days.The clinical symptoms,changes of heart rates,blood pressure,volume of urine,lactic acid dehydrogenase,creatine kinase,creatine kinase-MB,cardiac troponin Ⅰ and electrocardiogram were investigated before and after treatment.Results Treatment with L-carnitine improved the symptoms of hypoxic ischemic myocardial injury,the total effective rate was 93.3% (28/30),versus 66.7% (20/30) in control group,the difference was statistically significant(x2 =6.667,P =0.01).Heart rates of the experimental group were significantly improved after treatment(t =-6.131,P <0.01),compared with the control group,there were no significant differences (P > 0.05).Blood pressure and urine volume of experimental group both increased after treatment (P <0.05),compared with the control group,the differences were statistically significant (P < 0.05).Creatine kinase and creatine kinase-MB significantly decreased after treatment,compared with the control group (P < 0.05).A downward trend of cardiac troponin Ⅰ was observed in both groups,however,there was no statistically significant difference before and after treatment (P > 0.05).After treatment,electrocardiogram improvement rates were no significantly different between the two groups (P > 0.05).Conclusion L-camitine can contribute to protect hypoxic ischemic myocardial from further injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pediatric Emergency Medicine
Year:
2013
Type:
Article
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