Preparation of carboplatin-loaded albumin microsphere and its properties in vitro / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 91-1998.
Article
in Chinese
| WPRIM
| ID: wpr-598321
ABSTRACT
To prepare bio-degradable albumin microspheres containing carboplatin. METHODS:
Bovin serum albumin microspheres containing carboplatin were prepared by using emulsion-direct heat cross linking techniques.RESULTS:
The microsphere was yellow, powdery, with a mean diameter of 58.2 μm. The microphere loaded (11.26±0.48)% carboplatin. The trapping efficiency was (84.5±3.6)%. The pattern of drug releasing from the microspheres in vitro fitted to zero order release plot, with an initial burst in the first 2 hours. The releasing rate can be expressed by the follow equation Q=21.90+8.50 t (d), r=0.995 8. t50=3 d. Stored at 4 ℃ and 37 ℃ respectively for 3 months, the microspheres did not alter much in shape, size and drug content.CONCLUSIONS:
This method is simple, reproducible, having high drug trapping efficiency. The microsphere obtained is stable and release drug at a consistant rate in vitro, leading to a prosperity in clinical use.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
1998
Type:
Article
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