Protection of dexmedetomidine on cerebral injury in patients undergoing heart valve replacement surgery under cardiopulmonary bypass / 重庆医学

ABSTRACT

Objective To investigate protective effect of dexmedetomidine on cerebral injury in patients undergoing heart valve replacement surgery under cardiopulmonary bypass (CPB) .Methods 60 patients with CPB underwent cardiac valve replacement were randomly divided into observation group and control group ,and respectively given dexmedetomidine and saline ,before CPB (T1) ,aortic opening (T2) ,CPB (T3) and 6 hours after operation (T4) ,then tested jugular bulb oxygen saturation degree (SjvO2 ) , cerebral arteriovenous internal jugular venous oxygen content difference (Ca-jvO2 )and cerebral oxygen extraction rate(ERO2 ) ,and the plasma levels of S-100βprotein and plasma specific enolase (NSE) .Results In T2 ,T3 ,SjvO2 ,PaO2 increased ,Ca-jvO2 ,ERO2 decreased ,in T3 during rewarming ,SjvO2 ,PaO2 of observation group was significantly higher than control group ,Ca-jvO2 ,ERO2 was lower than that in control group ,there were significant difference between two groups (P<0 .05) .In T2 ,T3 ,T4 ,NSE and S-100βprotein concentration of water increased ,but that of observation group was significantly lower than that of control group ,there were significant differences between two groups (P<0 .05) .Conclusion Dexmedetomidine has cerebral protective effect .