The study on the correlation of renal function and plasma ammonia in patients with liver cirrhosis combined with hepatorenal syndrome / 重庆医学

ABSTRACT

Objective To study the correlation of renal function and plasma ammonia in patients with liver cirrhosis combined with hepatorenal syndrome .Methods The clinical data of 149 patients with liver cirrhosis who came to this hospital from February 2008 to April 2013 was collected .All the patients were divided into the HRS group (hepatorenal syndrome ,35 cases) and non-HRS group (non-hepatorenal syndrome ,114 cases) .The clinical datas and related biochemical indicators of two groups were analyzed and compared .Results The serum level of TB ,DB ,AST ,ALT ,BU ,CREA and NH3+ of the HRS group was statistically higher than that of the non-HRS group ,while the serum level of TP ,Alb ,NA and CL of the HRS group was statistically lower than that of the non-HRS group;results of Pearson′s analysis showed that the serum level of BU and CREA were positively correlated with NH3+ in HRS group .Conclusion The relationship between hepatorenal syndrome and plasma ammonia in patients with liver cir-rhosis is closely .Intestinal acidification can be used to reduce the risk of hepatorenal syndrome and hepatic encephalopathy .