The effect of triple therapy to the levels of serum IL-10,TGF-β1 and IL-17 in eldly patients with helicobater pylori associated gastritis / 重庆医学

ABSTRACT

Objective To observe the effect of triple therapy to the levels of serum interleukin 10(IL)-10 ,transforming growth factor beta 1(TGF-β1) and IL-17 in eldly patients with helicobater pylori associated gastritis .Methods 90 eldly patients with heli-cobater pylori associated gastritis were randomly divided into observation group and control group ,45 cases in each group ,the ob-servation group was given standard triple therapy ,the control group was separately given omeprazole treatment ,after 14 days , ELISA method was used to detect the levels of serum IL-10、TGF-β1 and IL-17 .Results Compared with before treatment ,the lev-els of IL-10、TGF-β1 and IL-17 in of the two groups had significantly reduced after treatment (P<0 .05);compared with the control group after treatment ,the levels of IL-10、TGF-β1 and IL-17 in observation group after treatment had significantly reduced (P<0 .05) .Compared with helicobater pylori negative and helicobater pylori positive patients of the experimental group after treatment , the levels of IL-10、TGF-β1 and IL-17 had significantly reduced(P<0 .05) .The levels of IL-10、TGF-β1 and IL-17 in serum of pa-tients of two groups before treatment showed significantly positive correlation (P<0 .05) .Conclusion The triple therapy could sig-nificant decrease the levels of serum IL-10、TGF-β1 and IL-17 ,it has good treatment effect .