Synergistic effect of Huang Lian Jie Du Decoction on sodium valproate in epileptic rats induced by lithium chloride-pilocarpine / 重庆医学
Chongqing Medicine
;
(36): 689-691,695, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-598900
ABSTRACT
Objective To investigate synergistic effect of Huang Lian Jie Du decoction (HLT) on sodium valproate(SVA) in epi-leptic rats by epileptic rats induced by lithium chloride-pilocarpine .Methods Epileptic rats were induced by intraperitoneal injection of lithium chloride and pilocarpine .The synergistic anti-epilepsy effect of HLT and SVA was investigated .The level of ALT ,AST , SVA in serum ,GSH-Px and MDA were determined at the end of a 4 week adminstration .Then the ultrastructure alteration of the liver were also observed by transmission electon microscope .Results The adminstration of SVA together with HLT can reduce be-havior of epileptic rats .Significant decrease in the level of ALT ,AST ,and SVA in serum of rats and noticeable increases in the ac-tivity of GSH-Px were observed in the co-administered groups compared with administere SVA alone group(P<0 .01) .At the same time ,light microscopic study indicates rats in co-administered SVA and high-dose HLT group has intacthepatic histology .Conclu-sion HLT could has synergistic anti-epileptic effect and relieve the hepatotoxoicity of SVA when co-administered .
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chongqing Medicine
Year:
2014
Type:
Article
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