Clinical significance of the changed serum thyroid function and immune content from patients with gestational hyperthyroidism / 中国医师杂志

ABSTRACT

Objective To explore the clinical value of changes of serum thyroid function and immune content from patients with gestational hyperthyroidism.Methods A total of 146 cases of patients with hyperthyroidism during pregnancy and 73 cases of patients with recurrence of hyperthyroidism after delivery were chosen as the experimental group,and 73 cases of patients without recurrence of hyperthyroidism after delivery were chosen as the control group.The thyroid function and thyroid-stimulating antibody (TSAb)concentrations at different period of pregnancy for two groups were tested.The thyroid function and TSAb concentrations after pregnancy of the two groups were also tested.Results At the mid and late period of pregnancy,the concentrations of free triiodothyronine (FT3)and free tetraiodothyronine (FF4) were significantly lower than early pregnancy.The concentrations of hypersensitive thyroid stimulating hormone (sTSH) and TSAb were increased gradually.The concentrations of FT3,FT4,and TSAb after pregnancy were all significantly higher than control group (P ＜ 0.05).Conclusions FT3,FT4,sTSH,and TSAb can be used for early diagnosis of hyperthyroidism during pregnancy,and have a certain predictive value for relapse after secretion.