Prediction of secondary structure and B-cell epitope of human IL-37 / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 648-650,653, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-599125
ABSTRACT
Objective:
To predict the secondary structure and B-cell epitope of human IL-37.Methods:
Based on IL-37b ami-no acid sequence, the secondary structure was predicted by SOPMA; hydrophilicity, flexibility, accessibility index were predicted by software of ProScale, Bcepred, respectively.Combined the results according to these methods , the B cell epitopes of IL-37b were pre-dicted.Results:
The second structure of IL-37b contained extended strand (31.65%), random coil (52.75%), alpha helix (8.26%), beta turn (7.34%) and the most possible epitopes of IL-37b were located in or adjacent to amino acid 21-27, 34-75, 175-192 , 213-215 .Conclusion:
These results will be helpful for the estimate of the epitopes and provide a theory basis for developing mon -oclonal antibodies against human IL-37.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2014
Type:
Article
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