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The influence of CYP4F2(rs2108622)gene polymorphism on the warfarin dose in old patients / 国际检验医学杂志
International Journal of Laboratory Medicine ; (12): 1400-1401,1404, 2014.
Article in Chinese | WPRIM | ID: wpr-599226
ABSTRACT
Objective To observe the effect of CYP4F2(rs2108622)polymorphism on the dose of warfarin in old patients(65 to 75 years old)who were treated with atrial fibrillation.Methods Sixty cases of old patients with atrial fibrillation were enrolled in the study.All the subjects had taken warfarin for 3 months,and the international normalized ratio(INR)maintained between 1.6 and 2.5.And the CYP4F2(rs2108622)variant were detected by PCR.Results The patients with CYP4F2(rs2108622)allele C/C scored significantly lower warfarin dose than patients with variant allele C/T and T/T (P < 0.05 ).Conclusion CYP4F2 (rs2108622)gene polymorphism have been related with warfarin dose in old patients.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2014 Type: Article