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Effects of timeshare administration of Jiaweisinisan on biological rhythm of rats with chronic stress / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 867-873,874, 2014.
Article in Chinese | WPRIM | ID: wpr-599241
ABSTRACT
Aim To study the effects of timeshare ad-ministration of Jiaweisinisan ( JWSNS ) on biological rhythm of rats with chronic stress. Methods Unpre-dictable mild chronic stress was used. Cosine rhythm analysis was adopted to observe and analyze the chan-ges of circadian rhythms of body temperature and se-cretion of 5-hydroxy tryptamine ( 5-HT ) , melatonin ( MT) and corticosterone ( CORT ) and the effects of JWSNS. Serum 5-HT,MT and CORT were detected by enzyme-linked immunosorbent assay. Results Three groups of administration of JWSNS had no inhibitory effects on weight gain in model rats,but improved the sucrose preference ( P Administration at 17 30 had biphasic regulatory effects on the peak and valley value,while administra-tion at 7 30 and 17 30 respectively mainly acted on the light phase,namely regulated the valley value. Rats with chronic stress showed delays of body temperature rhythm,namely postponed phase, which could only be inhibited by administration at 7 30 . There were de-creases in votatility and disorders in secretion rhythm, as was shown by dramatically accelerated phase of ser-um 5-HT, MT and CORT in rats with chronic stress. Administration of JWSNS at 17 30 or at 7 30 and 17 30 respectively had inhibitory effects on lower ser-um level of 5-HT in model rats ( P increase and the decreases in volatility. ConclusionAdministration of JWSNS at 7 30 achieves anti-de-pressant effects by regulating rhythms of hormones and neurotransmitters. Administration of JWSNS at 17 30 achieves anti-depressant effects by adjusting the secre-tion of hormones and neurotransmitters,while adminis- tration of JWSNS at 7 30 and 17 30 respectively a-chieves anti-depressant effects by those two above-men-tioned aspects.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2014 Type: Article