Analysis of Pseudomonas aeruginosa to carbapenem antimicrobial resistance / 中国基层医药

ABSTRACT

Objective To analyze the drug resistance of Pseudomonas aeruginosa to antibiotics carbapenems by analyzing clinical data and the results of bacterial culture of patients with Pseudomonas aeruginosa infection . Methods 160 patients with Pseudomonas aeruginosa infection were chosen as the research object ,firstly experimen-tal inspection of the strain resistance .Antimicrobial drug card including meropenem (MEM),imipenem(IMI),ceftazi-dime(CAZ),gentamicin(GEN),Amikacin(AK),ciprofloxacin(CIP),aztreonam(ATM),levofloxacin(LEV),me-zlocillin(MEZ),chloramphenicol(CMP),Pi La Shilling /tazobactam(TZP)and cefoperazone/Shubatan(SCF).In or-der to imipenem(IMI)and ceftazidime(CAZ)as substrate,the metallo beta lactamase phenotype screening .Results Pseudomonas aeruginosa resistant to CMP was the highest ,accounted for 93.75%.The MEM resistance rate ratio was 18.13%.2 Pseudomonas aeruginosa to meropenem sensitive rate was 81.88%,significantly higher than that of imi-penem sensitive rate(61.88%),the difference was statistically significant (χ2 =4.34,4.34,all P<0.05).Meropen-em sensitive Pseudomonas aeruginosa MIC≤1μg/mL strain ratio was 76.9%,significantly higher than that of imipen-em,MIC value of 2-4μg/mL strain ratio was 23.1%,significantly lower than that of imipenem ,the difference was sta-tistically significant(χ2 =5.43,5.43,all P<0.05).3 different substrates and inhibitors of metallo beta lactamase de-tection results showed that 32 strains of Pseudomonas aeruginosa metallo beta lactamase positive ,ratio of 19.4%.Taking CAZ as the low material was positive in 11 cases,21 cases were positive with IMI as substrate .Conclusion The re-sistance of Pseudomonas aeruginosa to antibiotics ,but sensitive to meropenem ,resistant strains of metallo beta lacta-mase expression rat .