Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
Biomolecules & Therapeutics
;
: 284-289, 2013.
Article
in English
| WPRIM
| ID: wpr-59931
ABSTRACT
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants
/
Blood Glucose
/
Passive Cutaneous Anaphylaxis
/
Cell Death
/
Cell Culture Techniques
/
Zea mays
/
Insulin-Secreting Cells
/
Polyphenols
/
Insulin
/
Anthocyanins
Limits:
Animals
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2013
Type:
Article
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