Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Induced by Urotensin II in Human Vascular Endothelial Cells
Biomolecules & Therapeutics
;
: 277-283, 2013.
Article
in English
| WPRIM
| ID: wpr-59932
ABSTRACT
In this study, we investigated the effects of a selective urotensin II (UII) receptor antagonist, SB-657510, on the inflammatory response induced by UII in human umbilical vein endothelial cells (EA.hy926) and human monocytes (U937). UII induced inflammatory activation of endothelial cells through expression of proinflammatory cytokines (IL-1beta and IL-6), adhesion molecules (VCAM-1), and tissue factor (TF), which facilitates the adhesion of monocytes to EA.hy926 cells. Treatment with SB-657510 significantly inhibited UII-induced expression of IL-1beta, IL-6, and VCAM-1 in EA.hy926 cells. Further, SB-657510 dramatically blocked the UII-induced increase in adhesion between U937 and EA.hy926 cells. In addition, SB-657510 remarkably reduced UII-induced expression of TF in EA.hy926 cells. Taken together, our results demonstrate that the UII antagonist SB-657510 decreases the progression of inflammation induced by UII in endothelial cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thromboplastin
/
Monocytes
/
Cytokines
/
Interleukin-6
/
Vascular Cell Adhesion Molecule-1
/
Endothelial Cells
/
Human Umbilical Vein Endothelial Cells
/
Inflammation
Limits:
Humans
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2013
Type:
Article
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