Values of multiple biochemical indexes in diagnosis of early diabetic nephropathy / 国际检验医学杂志

ABSTRACT

Objective To explore the diagnostic values of serum cystatin(CysC),retinol binding protein(RBP),β2 microglobulin (β2-MG),and urine microalbumin(mALB)and transferrin(TRF )in the diagnosis of early diabetic nephropathy(DN).Methods 118 patients with diabetes mellitus(DM)were divided into three groups according to the urinary albumin excretion rate (UAER), simple DM group,early DN group and clinical stage DN group.The immunity turbidimetry method was applied to measure the ser-um CysC,RBP,β2-MG and urine mALB,TRF;the enzymatic method was applied to measure the serum Cr;the rate method was applied to measure the serum Bun.The detection results were analyzed statistically.Results serum CysC,RBP,β2-MG and urine mALB,TRF levels in the early DN group and the clinical stage DN group were significantly higher then those in the simple DM group,the differences had statistical significance(P 0.05 ),serum Cr and Bun levels in the clinical stage DN group were significantly higher than those in the simple DM group with statistical difference(P <0.05).Conclu-sion Serum CysC,RBP,β2-MG and urine mALB,TRF levels in the patients with DN are significantly increased,which has the im-portant clinical value for early diagnosing and monitoring DN.