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Meta analysis of T-SPOT.TB test for diagnosing tuberculous meningitis / 重庆医学
Chongqing Medicine ; (36): 3299-3301,3304, 2014.
Article in Chinese | WPRIM | ID: wpr-599499
ABSTRACT
Objective To investigate the diagnostic value of the T-SPOT.TB test for diagnosing tuberculous meningitis(TBM) by meta-analysis.Methods A systematic retrieval from the databases of PubMed,EMBASE,etc.was performed.The literature on the T-SPOT.TB test for diagnosing TBM was collected.Two reviewers independently screened the literature,extracted the data and judged the quality.The meta analysis was conducted by the Meta-Disc 1.4 software.Results 8 articles were included,involving 425 patients including 232 cases of TBM.In the peripheral blood group,the combined sensitivity was 80%(95%CI0.74-0.85),the combined specificity was 74%(95%CI0.67-0.80),the area under the curve(AUC)of summary receiver operating characteristic (SROC)was 0.858 7;the diagnostic odds ratio(DOR)was 15.50.In the CSF group,the combined sensitivity was 76%(95%CI0.70-0.82),the combined specificity was 83%(95%CI0.77-0.88),AUC was 0.892 7;DOR was 22.62.Conclusion Adopting the T-SPOT.TB test conduces to increase the diagnostic rate of TBM.The diagnostic accuracy of the T-SPOT.TB test for CSF may be higher than that for peripheral blood.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study / Systematic reviews Language: Chinese Journal: Chongqing Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study / Systematic reviews Language: Chinese Journal: Chongqing Medicine Year: 2014 Type: Article