Influence of hippophae rhamnoides on neuropeptide Y,gastric emptying and body fat in children with func-tional dyspepsia / 中国基层医药

ABSTRACT

Objective To explore the effect of hippophae rhamnoides on the level of plasma appetite factors neuropeptide Y ,the gastric motility and on their body fat in children with functional dyspepsia .Methods A hundred and twenty children with functional dyspepsia were simple random sampled divided into the three groups :Group Ⅰ( treated with hippophae rhamnoides ) ,Group Ⅱ( treated with domperidone ) , and Group Ⅲ( treated with hippophae rhamnoides plus domperidone ) .The treatment lasted for eight weeks .The level of plasma neuropeptide Y ( NPY) were measured before and after treatment .All patients underwent a gastric emptying ( GE) test by ultrasound ( US) to measure the rate of postprandial gastric antrum residual ,at 30min,60min,90min and 120min.The average value of subcutaneous fat,body fat percentage,upper arm girth,weight and height were also measured .Results There were no statistical difference between the level of NPY in plasma of groupⅠ,ⅡandⅢbefore treatment,which were (107.52 ±24.12)ng/L, (114.63 ±17.95)ng/L and(114.56 ±25.10)ng/L(F=1.307,P>0.05).After treatment,there were statistical difference between the level of NPY in plasma of groupⅠ,ⅡandⅢ,which were (137.38 ±29.86) ng/L,(121.43 ± 13.78)ng/L and (149.27 ±31.9)ng/L.The level of NPY in plasma of groupⅠandⅢwere markedly increased after treatment(t=4.95,5.40,all P0.05). Conclusion In children′s functional dyspepsia ,the hippophae rhamnoides increases the level of appetite factor neu-ropeptide Y,The child′s body fat increases markedly and physical growth also has obvious improvement .