Studies on degradation kinetics of paeoniflorin-6-O’- benzenesulfonate in vitro / 安徽医科大学学报
Acta Universitatis Medicinalis Anhui
;
(6): 1269-1273,1274, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-599771
ABSTRACT
Objective To investigate the degradation kinetics of paeoniflorin-6-O’- benzenesulfonate ( CP-25 ) in vitro. Methods The homogenates of liver and intestine were prepared in vitro, and concentrations of CP-25 in ho-mogenates were detected by HPLC. Results CP-25 was obviously degradable in liver and intestine homogenates, and half life of degradation was decreased when levels of homogenates increased;the metabolisms of CP-25 in dif-ferent homogenates of intestine were diverse, the metabolic actions in duodenum and colon were weaker than those of jejunum and ileum. Conclusion Oral administration of CP-25 suffers first pass elimination from intestine and liver, which suggests the absorption of CP-25 could be further improved by appropriate pharmaceutical preparations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Universitatis Medicinalis Anhui
Year:
2014
Type:
Article
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