Analysis on relation between peripheral blood CD4 + regulatory T cells and curative effect in patients with chronic hepatitis C / 国际检验医学杂志

ABSTRACT

Objective To study the relationship between peripheral blood regulatory T cells CD4 + and the antiviral effect in the patients with chronic hepatitis C.Methods 128 patients with chronic hepatitis C after antiviral treatment and follow-up were col-lected as the experimental group,the peripheral blood was respectively extracted before treatment and after treatment and at 24-week follow-up.The flow cytometry was adopted to detect CD4 + percentage.Moreover the liver function indexes and HCV-RNA quantitation were detected.80 individuals were selected as the normal control group.Results HCV-RNA quantitation,AST,ALT, CD4 + (%)had statistical differences between the the experimental group and the control group(P <0.05);the HCV-RNA quantita-tion,AST,ALT,CD4 + (%)levels after treatment and 24-week follow-up in the experiment group were significantly decreased(P <0.05).Conclusion The antiviral treatment can effectively reduce the damage of chronic hepatitis C,raise the cure rate,reduce the liver damage.The peripheral blood CD4 + regulatory T cells can be used as the index of the antiviral treatment efficacy and hepatitis C virus(HCV)infection.