Distribution and drug susceptibility testing in patients with hospital-acquired Pseudomonas aeruginosa infection / 国际检验医学杂志

ABSTRACT

Objective To study the distribution characteristics and the drug susceptibility testing in the patients with hospital-acquired Pseudomonas aeruginosa(PA)infection to provide reference for clinical treatment.Methods The sputum specimens from 484 cases of hospital-acquired infection were performed the bacterial culture identification and the drug susceptibility testing for studying the Pseudomonas aeruginosa infection situation and the drug sensitivity characteristics.Results Among 484 cases of hos-pital-acquired pneumonia,389 strains of Gram-negative bacilli were detected out,accounting for 80.37%,Pseudomonas aeruginosa was predominant,207 strains were detected out,accounting for 42.77%;95 strains were Gram-positive cocci,accounting for 19.63%.the constituent ratio of Gram-negative bacilli and Gram-positive cocci had the statistical difference (χ2 = 354.38,P =0.000,P <0.05).The Pseudomonas aeruginosa infection revealed the increasing trend;in the age distribution,the majority were the elderly aged more than 51 years old,accounting for 42.51%;the drug susceptibility testing showed that cefuroxime,ciprofloxacin, levofloxacin and ticarcillin/clavulanic acid had the higher resistance rates,which reached 96.6%,65.3%,49.3% and 49.3% re-spectively,imipenem-resistant strains was not found.Conclusion Pseudomonas aeruginosa is an important bacterium of hospital-ac-quired bacterial infections,multi-drug resistance is common,the antimicrobial drugs should be rationally used during clinical treat-ment course according to the drug susceptibility testing.