Prevalence and risk factors of hyperuricemia in Shandong Province / 军事医学

ABSTRACT

Objective To analyze the prevalence and risk factors of the hyperuricemia ( HUA) in the adult population (aged≥20)in Shandong Province.Methods A cross-sectional survey was conducted among 11 234 subjects(8399 males and 2835 females)selected in a randomized, stratified study between January and December of 2012.The serum samples were collected and some biochemical indicators were assayed including serum uric acid (SUA), glucose, blood lipids, liver function and renal function .The body height , body mass and blood pressure were also measured , and the body mass index (BMI)was calculated.Multiple linear regression was used to clarify the contributions of different variables to SUA .The risk factors of HUA were analyzed using univariate and multivariate logistic regression analysis .Results The overall incidence of HUA was 15.71%,and was 18.89% in men and 6.31% in women, respectively.After age 35,the level of SUA declined with age in males.However,the opposite was true in women .Our results also indicated that drinking , obesity, hyper-triglyceridemia , hypertension , serum creatinine ( SCr ) , blood urea nitrogen ( BUN ) , alanine aminotransferase ( ALT ) , serum gamma-glutamyltransferase ( GGT ) were associated with HUA in men while hypertension , low-density lipoprotein, hyper-triglyceridemia,ALT,SCr and BUN were related to HUA in women .Conclusion HUA is prevalent in Shandong Province .Drinking,obesity,hypertension,abnormal liver and renal functions might increase the risk of HUA while changing lifestyle by decreasing alcohol consumption , adopting a proper diet and controlling hypertension and obesity might decrease the risk of HUA .