Gucocorticoid receptor:a potential target for depression treatment / 军事医学
Military Medical Sciences
;
(12): 908-911,917, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-600045
ABSTRACT
Depression is a serious mental disorder characterized by lasting anhedonia and anorexia .The pathophysiology of depression is complicated , which is related to many neuroendocrine disturbances .Increased levels of glucocorticoid hor-mones and hyperactivity of the hypothalamus pituitary adrenal ( HPA) axis are the most consistent and typical pathophysio-logical alternations in patients with major depression , which are possibly caused by altered functions of the receptor of glu-cocorticoid hormones , the glucocorticoid receptor ( GR) .Promoting the expression and function of GR and restoring the im-paired feedback inhibition of the HPA axis seem to be particularly important for the therapeutic efficacy of antidepressants . In this review, the role of GR in the development and resolution of depression is discussed .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Military Medical Sciences
Year:
2014
Type:
Article
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