Curative Effect of Nimodipine on Vascular Cognitive Impairment no Dementia / 中国药师

ABSTRACT

Objective: To investigate the curative effect of nimodipine on vascular cognitive impairment no dementia. Methods:Totally 76 patients with vascular cognitive impairment no dementia were randomly divided into group A with 39 cases and group B with 37 cases. The two groups were given conventional treatment ( aspirin tablets, 100 mg · d-1 , and atorvastatin calcium tablets, 20 mg·d-1 , The patients in group A were treated with nimodipine additionally, 30 mg, po, tid. The course of treatment of the two groups was two weeks. The Montreal Cognitive Assessment ( MOCA) and mini-mental state examination ( MMSE) were used to evaluate the efficacy of the two groups before and after the treatment. Results:After the treatment, MMSE and MOCA scores in group A were increased significantly compared with those before the treatment (P 0. 05). The total efficacy in group A was notably higher than that in group B (P < 0. 05). No patient experienced adverse drug reactions in both groups. Conclusion: Nimodipine has preventive and therapeutic effects on vascular cognitive impairment no dementia.