Regulation of Stem Cells Based on the Biomechanics and Measurement of their Associated Physical Properties / 天津医药

ABSTRACT

Stem cells transplantation had been proved to be effective in many clinical diseases. However, microenvi-ronment can influence their growth, migration and differentiation. Under chemical microenvironment, such as hypoxia, neu-ral growing factors and different kinds of ions, stem cells had been intensively studied while little is known about their perfor-mance under physical microenvironment. The effects of mechanical forces, elasticity and rigidity of the matrix of stem cells are still to be further investigated. This article is to summarize how microenvironment controls the fate of stem cells and to re-view the measurement of the mechanical properties.