Expression of Epidermal Growth Factor Related Peptides, EGF-R, and c-erbB-2 and Their Relationship with the Prognostic Factors in Gastric Carcinoma
Korean Journal of Pathology
;
: 1039-1046, 1999.
Article
in Korean
| WPRIM
| ID: wpr-60009
ABSTRACT
Recent investigations have revealed that autocrine growth factors and their receptors are closely related and play an important role in controlling cancer cell growth. We performed an immunohistochemical study on the expression of epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGF-R), c-erbB-2, and PCNA labelling index in 60 cases of human gastric carcinomas. TGF-alpha was detected in 38 cases (63.3%), EGF in 26 cases (43.3%), EGF-R in 44 cases (73.3%), and c-erbB-2 in 18 cases (30%). These growth factors, EGF-R and c-erbB-2, were found more often in advanced gastric cancers. The PCNA labeling index was significantly higher in tumors with the expression of EGF-R or c-erbB-2. Tumors with simultaneous expression of EGF, TGF-alpha, EGF-R and c-erbB-2 was associated with a high PCNA labeling index. A correlation was observed between the synchronous expression of growth factors and its receptors and histological differentiation. The results suggest that the expression of EGF, TGF-alpha, EGF-R and c-erbB-2 are closely related and plays an important role in the growth and progression of human gastric carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Stomach Neoplasms
/
Transforming Growth Factor alpha
/
Proliferating Cell Nuclear Antigen
/
Intercellular Signaling Peptides and Proteins
/
Epidermal Growth Factor
/
ErbB Receptors
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
1999
Type:
Article
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