Clinical effect of different doses of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding / 中国基层医药

ABSTRACT

Objective To analyze the effect and safety of different doses of mifepristone treating perimenopa-usal dysfunctional uterine bleeding.Methods 80 patients with perimenopausal dysfunctional uterine bleeding were collected.According to the medicine of 5,10mg,25mg mg doses,80 cases were divided into the low dose group (n=26),middle dose group (n=26) and high dose group (n=28).The treatment results,endometrial thickness change, sex hormone level change and the adverse reaction were observed after 3 months.Results In terms of treatment effect,the effective rate in the middle dose group (92.3%) and high dose group (82.1%) were better than that of the low dose group(61.5%)(F=3.98,P<0.05);The inhibitory effect of endometrium in the middle dose group and high dose group were superior to the low dose group( F=4.34,P<0.05);All three groups of sex hormone level was significantly lower in the body;Middle and high dose group of the adverse reactions of treatment process was more,the adverse reaction happening far higher than that of the low dose and dose group (F=3.97,P<0.05). Conclusion 10mg mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding has good effect, less adverse reactions,which is worthy of clinical application.