The Relativity Between the Expression of Bcl-2,Ki-67, C-myc and Prognosis of Patients with Malignant Lymphoma / 天津医药
Tianjin Medical Journal
;
(12): 832-834,后插1, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-600253
ABSTRACT
Objective:
To study the relationship between the expressions of Bel -2, Ki -67, C -myc and prognosis in patients given chemotherapy for malignant lymphoma (ML).Methods:
The expressions of Bel-2, Ki-67 and C-myc were measured by immunohistochemistry (IHC) in paraffin-embedded samples of 65 ML cases who received chemotherapy. The survival analysis was done by the Kaplan -Meier method and Log -rank test.Results:
For patients with non -Hodgkin lymphoma (NHL) who received chemotherapy, the 3-year disease free survival (DFS) was 22.22% in Bcl-2(+) group compared with that of 55.56% in Bcl-2 (-) group. The difference of DFS was significant between the two groups. Meanwhile, for ML patients, the 3-year DFS was 37.50% in Ki-67(+) group, and 61.54% in Ki-67(-) group respectively(P < 0.05).Conclusion:
The expressions of Bcl-2 and Ki-67 were closely related with relapse after chemotherapy in patients with ML. They were useful molecular makers for predicting the prognosis in patients with ML after chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Tianjin Medical Journal
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS