Effect of defibrase on APTT,PT and blood rheology in patients at the acute stage of cerebral infarction / 中国生化药物杂志

ABSTRACT

Objective To observe the effect of defibrase on activated partial thromboplastin time (APTT),prothrombin time (PT)and the blood rheology at the acute stage of cerebral infarction.Methods 46 cases of cerebral infarction were selected in the Nanyang City Center Hospital.They were randomly divided into two groups;23 cases of control group,with regular treatment of 5% low molecular dextran and venoruton injection,intravenous drip,one week for a course,for two courses of treatment;23 cases of experimental group,with 10U defibrase,intravenous drip,every two days,one week for a course,for two courses of treatment.After treatment,APTT,PT and blood rheology were compared before and after treatment.Results APTT were improved in both groups after treatment,and APTT in experimental group was higher than that in control group,and the difference was statistically significant (P<0.05 );PT were improved in both groups after treatment,and the experimental group was higher than that in control group,and the difference was statistically significant (P<0.05);the blood rheology were improved in two groups after treatment (including high shear rate,low shear rate,plasma viscosity,erythrocyte deposited and fibrinogen),and the high shear rate,plasma viscosity,and fibrinogen of experimental group were lower than those of control group,and the differences was statistically significant (P<0.05 ).Conclusion Defibrase could obviously improve the APTT,PT and hemorheology indexes of cerebral infarction at the acute stage,which gives a clinical guidance.