The efficacy and safety of tranexamic acid in patients undergoing off-pump coronary bypass grafting:a systematic review and meta-analysis / 重庆医学

ABSTRACT

Objective The aim of this study is to evaluate the efficacy and safety of tranexamic acid for patients undergoing off-pump coronary bypass grafting .Methods The MEDLINE ,Embase were searched for randomized controlled trials(RCTs) of patients undergoing off-pump coronary bypass grafting .And the Cochrane Collaboration′s RevMan 5 .2 software was used to evalu-ate the quality of the included studies and to perform the meta-analyses .Results 10 trials involving 851 patients were included . Tranexamic acid significantly reduced the postoperative blood loss (24 hSD= -208 .41 ,95% CI-311 .48 - -105 .35 ,P<0 .000 1) ,overall risk of allogeneic blood component transfusion(RR=0 .47 ,95% CI0 .33 -0 .66 ,P< 0 .000 1) ,and packed red blood cell transfusions(RR=0 .60 ,95% CI0 .49-0 .74 ,P<0 .001) .But no association was found between tranexamic acid and ad-verse thrombotic events .Conclusion Tranexamic acid significantly reduced the postoperative blood loss and overall risk of allogene-ic in patients undergoing OPCAB .However ,due to the limited quality of the included studies ,further evidence with more high quali-ty studies is still needed .