Study on the relationship between platelet counts and fibrinogen level and its clinicopathological characteristics / 重庆医学

ABSTRACT

Objective To explore the associations of preoperative plasma levels of platelet and fibrinogen with clinicopatho-logic parameters in rectal cancer patients after curative resection .Methods From January 2011 to February 2014 ,a total of 302 rec-tal cancer patients underwent curative resection .And their relevant clinical data were reviewed .The preoperative plasma levels of platelet and fibrinogen were examined ,the correlation of clinicopathologic findings .The logistic regression analysis was used for for multivariate analysis .Results (1)Elevated plasma levels of platelet were associated with histologic grade ,gross type ,degree of dif-ferentiation ,invasion depth ,tumor stage and lymph node involvement(P0 .05) .(3)Multivariate analysis showed that the platelet count ,fibrinogen ,ethnic ,degree of differentiation ,gross type were independent risk factors to rectal cancer(P<0 .01) .(3)PLT and FIB were correlated in tumor metastases(r=0 .348 ,P<0 .01) ,and the combined detection of them could increase the sensitivity and accuracy on prediction of tumor metastases .Conclusion Elevated plasma levels of platelet and fibrinogen are both associated with metastases in rectal cancer ,and the combined detection of them are important for the early diagnosis of rectal cancer metastases .