Determination of Chloride and Sulfate in Lithium Carbonate Crude Drug by Ion Chromatography / 中国药师
China Pharmacist
;
(12): 324-325,326, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-600509
ABSTRACT
Objective:
To establish a method for the determination of chloride and sulfate in lithium carbonate crude drug by sup-pressed ion chromatography.Methods:
The analysis column and the guard column was Thermo IonPac AS11(250 mm × 4 mm) and IonPac AG 11(50 mm ×4 mm), respectively. Potassium hydroxide solution(10 mmol·L-1) generated by an eluent generator(EG) was used as the eluent at a flow rate of 1. 0 ml·min-1 . And the temperature of column and conductivity cell was 30℃ and 35℃, re-spectively. The suppressor electric current was 36 mA, and the injection volume was 10 μl.Results:
The linear range of chloride ion and sulfate ion was 1. 0-20μg·ml-1 with r of 0. 995 1 and 0. 997 3,respectively, and the recovery was 106. 6%(RSD=2. 6%,n=6) and 100. 3%(RSD=1. 9%,n=6), respectively.Conclusion:
The method is accurate and reliable, and can be used in the determina-tion of chloride and sulfate in lithium carbonate crude drug.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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