Hydroxysafflor yellow A inhibits VSMCs proliferation via PCNA and MEK-ERK1/2 / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 984-987,988, 2015.
Article
in Zh
| WPRIM
| ID: wpr-600703
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WPRO
ABSTRACT
Abstrac:Aim To study the effect of hydroxysafflor yellow A ( HYSA ) on the proliferation of vascular smooth muscle cells ( VSMCs) and the related molecu-lar mechanism. Methods The inhibitory effects of hydroxysafflor yellow A on VSMC proliferation was de-tected using cell culture, MTT assay, Western blot and immunohistochemical staining. Results The results showed that HYSA inhibited cell proliferation induced by PDGF in a dose-dependent (5,10,20,40 μmol· L-1 ) manner, reduced proliferating cell nuclear anti-gen ( PCNA ) expression and blocked PDGFR-MEK-ERK1/2 signaling pathway activated by PDGF in VSMCs. Conclusion HYSA inhibits VSMCs prolifer-ation via reducing the expression of PCNA and blocking signal transduction of MEK-ERK1/2 in VSMCs.
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WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2015
Type:
Article