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Determination of Residual Organic Solvents in Fenticonazole Nitrate by Headspace Gas Chromatography / 中国药师
China Pharmacist ; (12): 18-19,20, 2015.
Article in Chinese | WPRIM | ID: wpr-600719
ABSTRACT

Objective:

To establish a method for the determination of dichloromethane, methanol and ethanol in fenticonazole ni-trate.

Methods:

The samples were detected by headspace GC. The column was OV-1301(30 m × 0. 53 mm,3. 0 μm), the detector was FID with nitrogen as the carrier gas, the detector temperature was 250 ℃ and the injector temperature was 200 ℃.

Results:

The linear range of dichloromethane, methanol and ethanol was 2. 436-21. 924(r=0. 998 8), 12. 268-110. 412(r=0. 999 5) and 20. 052-180. 468 μg·ml-1(r=0. 996 9) with the average recovery of 99. 30% (RSD=2. 36%), 100. 21%(RSD=1. 07%) and 100. 15%(RSD=1. 21%)(n=9), respectively.

Conclusion:

The detection method is sensitive, accurate and reliable, and can be used in the quality control of fenticonazole nitrate.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article