Meta-Analysis on the relationship between children,s high iodine goiter and excessive iodine / 重庆医学

ABSTRACT

Objective To comprehensively evaluate the relationship between children's high iodine goiter and excessive iodine . Methods A computerized literature search was carried out to collect articles published before 2014 in electronic databases CBM , WabFang ,VIP ,CNKI ,PubMed ,EMbase ,Ovid and Cochrane Library .The study type was randomized controlled trial or quasi‐ran‐domized control trial .Literature was analyzed by RevMan5 .0 software ,then calculated and combine RR and 95% CI .Publication bi‐as of Meta analysis was evaluated by Begg's test ,Egger's test and Macaskill's test .The result stability of Meta analysis was tested by sensibility analysis .Results A total of 10 controlled before and after studies were included in our meta‐analysis .The result showed that the iodine content of 150 -300 μg/L (RR1 .54 ;95% CI1 .14 -2 .07);301 -600 μg/L (RR2 .33;95% CI1 .43 -3 .82);601-900 μg/L (RR2 .7295% CI1 .01-7 .33) and greater than 900μg/L (RR2 .41 ;95% CI1 .38-4 .23) would result in chil‐dren goiter .Conclusion Iodine content greater than 150 μg/L would result in children goiter .