Value of serum microRNA-199a/b-3p on early diagnosis of hepatocellular carci-noma / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 683-685,689, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-600854
Responsible library:
WPRO
ABSTRACT
Objective:
To analyze the expression levels of serum microRNA-199a/b-3p ( miR-199-3p) in hepatocellular carcinoma (HCC) patients and to explore whether miR-199a/b-3p could be a novel biomarker of early HCC.Methods:
Patients with normal liver,liver cirrhosis and early HCC in clinic were included in this study.Blood samples of the patients were collected for analy-sis.Real time quantitative PCR technique was used to measure the expression level of serum miRNA-199a/b-3p.The AFP expression was got from clinical data.Results:
Comparing with normal liver and liver cirrhosis patients, miRNA-199a/b-3p presented lower expressions in early HCC patients (P<0.05);the accuracy and positive rate of serum miR-199a/b-3p detection in cirrhosis and HCC were better than AFP detection.Conclusion:
Data indicated that miRNA-199a/b-3p had diagnostic value for indicating liver cirrhosis and early HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Screening study
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2015
Type:
Article
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