Determination of Residual Organic Solvents in Bromfenac Sodium by Headspace Gas Chromatography / 中国药师
China Pharmacist
;
(12): 888-889,925, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-600897
ABSTRACT
Objective:
To establish a headspace capillary GC method for the determination of residual solvents in bromfenac sodi-um.Methods:
A headspace GC was used to separate the residual solvents on an HP-5 capillary column with an FID detector. The car-rier gas was nitrogen at the flow rate of 0. 8 ml·min-1 . The temperature of the injector was 200 ℃ and that of the FID was 250 ℃. The programmed column temperature was set as followsmaintained at 40℃ for 10 min, and then raised to 150℃ at the rate of 30℃·min-1 and maintained for 5 min. The containers of headspace injector were in equilibrium at 100 ℃ for 20 min. Dimethyl sulfoxide was used as the solvent. The amount of the residual solvents, such as methylbenzene, isopropanol, dichloromethane, methanol and iso-propyl ether was calculated by an external standard method.Results:
All the solvents could be completely separated with good linear relationship. The average recovery of the five solvents was 98. 9%( RSD =2. 01%),99. 2% ( RSD =1. 95%),99. 6% ( RSD =1. 65%),100. 5%(RSD=1. 38%)and 100. 8%(RSD=1. 36%)(n=9),respectively.Conclusion:
The method is simple and accu-rate in the determination of the five residual solvents in bromfenac sodium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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