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Expressions of IL-6 and IL-8 in lung injuries induced by blunt chest trauma / 重庆医学
Chongqing Medicine ; (36): 1317-1318,1321, 2015.
Article in Zh | WPRIM | ID: wpr-601010
Responsible library: WPRO
ABSTRACT
Objective To study the expression of IL-6 and IL-8 in the lung injuries induced by blunt chest trauma under the closure and open state of glottis.Methods The expressions of IL-6 and IL-8 mRNA were detected by RT-PCR in injuried lung tis-sues under the closed and open glottis states snd the control lung tissues at designed different time points.Results The expressions of IL-6 and IL-8 mRNA at 4,8,12h in the closed glottis group were obviously higher than those in the open glttis group (P <0.05) and the expressions at designed various time points in the injured lung tissue were higher than those in the control lung tissues (P <0.05).The change rule of IL-6 and IL-8 mRNA expression in the control group,closed glottis group and open glottis group was similar,the expression was up-regulated.Conclusion IL-6 and IL-8 might play an important role in the occurrence and develop-ment of functional lesion in the injured lung by blunt chest trauma.
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Full text: 1 Index: WPRIM Language: Zh Journal: Chongqing Medicine Year: 2015 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chongqing Medicine Year: 2015 Type: Article