Change of CD45RA+and CD45RO+T cell in peripheral blood in peripheral T-cell lymphoma patients before and after CHOP chemotherapy / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 531-533,536, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-601051
ABSTRACT
Objective:
To explore the change of initial and memory T cells in peripheral blood and their clinical significance in peripheral T cell lymphoma patients( PTCL) before and after CHOP chemotherapy.Methods:
The proportion of CD4+CD45RA+T cells and CD4+CD45RO+T cells,CD8+CD45RA+T cells and CD8+CD45RO+T cells in peripheral blood from 20 PTCL patients before and after chemotherapy was detected by flow cytometry, the relationship between curative effect and T cell subset was further analyzed.Results:
Before treatment,the proportion of CD4+and CD4+CD45RO+T cells in PTCL patients was significantly lower than that from the control group,while the proportion of CD4+CD45RA+,CD8+,CD8+CD45RO+and CD8+CD45RA+T cells was significantly higher( P<0.05 );after treatment, proportion of CD4+, CD4+CD45RO+T was significantly increased, CD4+CD45RA+, CD8+, CD8+CD45RO+,CD8+CD45RA+T was slightly decreased( P<0.05).Before and after treatment,higher proportion of CD4+CD45RA+T cells was found in response group compared with no response group.Conclusion:
CHOP chemotherapy might influence the thymic output function in PTCL patients,patients with higher thymic output function may have better response to chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2015
Type:
Article
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