The correlation analysis of Helicobacter pylori infection and carbohydrate antigen 724 / 国际检验医学杂志

ABSTRACT

Objective To investigate the correlation of Helicobacter pylori (HP) infection and serum carbohydrate antigen 724 (CA724) level .Methods 229 patients with HP infection hospitalized in gastroenterology department were enrolled in the observa‐tion group ,and patients were divided into different disease group according to the results of diagnosis .Other 100 healthy people , conducted physical examination ,were enrolled in the healthy control group .The HP infection was detected by 13C‐urea breath test and the serum CA724 level was detected by chemiluminescent immunoassay .Results The HP value and serum CA724 levels in each disease group were higher than those in the healthy control group ,with significant differences(P0 .05) ,except the duodenal group .The serum CA724 level was highest in the gastric cancer group ,there was no statistical differences between each disease groups(P>0 .05) ,except the gastric cancer group .The serum CA724 level was positively correlated with HP value in patients with HP infection(r=0 .331 ,P<0 .01) .Conclusion HP infection may correlate with serum CA724 level .The serum CA724 level in the gastric cancer group increased more significantly ,in other disease groups increased steadily .Dynamic observation of serum CA724 level in patients with upper gastrointestinal tract disease associated with HP infection could be helpful for early diagnosis and pre‐vention of aggravation of lesions ,and could provide effective diagnosis basis for early detection of upper gastrointestinal tract le‐sions ,such as gastric cancer .