Effect of risperidone on S100 B protein and its intervention on relapse of heroin addicts / 中国生化药物杂志

ABSTRACT

Objective To investigate the effect of risperidone on S100B protein and its intervention on the relapse of heroin addicts. Methods From January 2014 to March 2014, 70 cases heroin addicts in the second detection center in Xining were selected as objects, three patients dropped out, and the left were randomly divided into control group(n=33) and experimental group(n=34) , which were given detoxification for 10 days, rehabilitation for 5 days, while the experimental group were given risperidone intervention.The condition of craving degree for heroin, relapse and incidence of adverse reactions between two groups were compared.Serum S100B protein levels were detected by ELISA.The efficacy of risperidone was analyzed.Results The craving degree for heroin between two groups was of no significant differences, after drug treatment, the craving degree for heroin of experimental group were significantly lower than those of control group at the time-point of hospital discharge, 1 months after discharging and 3 months after discharging(P=0.013, P =0.008, P =0.005).The differences of relapse condition between two groups in 3 months after discharging were statistically significant (P=0.003), the relapse incidence of experimental group(11.8%) was significant lower than that of control group(54.5%). Besides, the differences of relapse condition among different craving degree groups were statistically significant in two groups respectively(P=0.005, P=0.008).Serum S100B protein levels of experimental group , in different periods were lower than those of control group, with statistical significance ( P<0.05); There were 5 cases of insomnia, 3 cases of headache, 3 cases of thirsty, 2 cases of mild extrapyramidal symptoms in test group, but all above were mild and relieved on their own after withdrawal, no similar symptoms were observed in control group.Conclusion Risperidone intervention is a safe and effective method to prevent heroin addicts from relapsing, it maybe with the mechanism of reducing the levels of serum S100B protein, but it needs further research and efforts to put it in clinical applications of herion addiction treatment.