Expression and clinical significance of VEGF and Id-1 in ccervical cancer tissues / 中国基层医药

ABSTRACT

Objective To investigate the expression VEGF and Id -1 and its possible relationship with the c1inical pathological features of cervical cancer .Methods The expression of VEGF and Id -1 were examined in cer-vical cancer and normal tissues by immunohistochemical SP technique .Results The positive expression rate of VEGF in cervical cancer was 80.00%(48/60),which was significantly higher than that in normal tissues 6.67%(2/30)(P<0.01);The positive expression rate of Id -1 protein in cervical cancer was 73.34%(44/60),which was significantly higher than that in normal tissues 10.00%(3/30)(P<0.01);The expressions of VEGF and Id -1 were positively correlated with the degree of differentiation ,vascular invasion,and FIGO stage(P<0.05),and while was not significantly associated with age ,tumor size,lymph node metastasis ,and pathologic types .Expression of VEGF was positively related with expression of Id -1 in cervical cancer tissues(r=0.642,P=0.000).Multiple regression anal-ysis showed thatVEGF,Id -1,differentiation,vascular invasion,and FIGO were independent prognosis factors for cervical cancer .Conclusion The expressions of VEGF and Id -1 are correlated with the development of cervical cancer.Detection of the expression of VEGF and Id -1 in cervical cancer can predict the metastasis and prognosis , which can provide the basis for clinical targeted therapy .