Anti-CD137 mAb Deletes Both Donor CD4+ and CD8+ T Cells in Acute Graft-versus-host Disease
Immune Network
;
: 428-430, 2011.
Article
in English
| WPRIM
| ID: wpr-60127
ABSTRACT
We previously demonstrated that in vivo engagement of CD137, a member of TNF receptor superfamily, can delete allorective CD4+ T cells through the induction of activation-induced cell death (AICD) in chronic graft-versus-host disease (cGVHD) and subsequently reverse established cGVHD. In this study, we further showed that agonistic anti-CD137 mAb was highly effective in triggering AICD of donor CD8+ T cells as well as donor CD4+ T cells in the C57BL/6-->unirradiated (C57BL/6 x DBA/2)F1 acute GVHD model. Our results suggest that strong allostimulation should facilitate AICD of both alloreactive CD4+ and CD8+ T cells induced by CD137 stimulation. Therefore, depletion of pathogenic T cells using agonistic anti-CD137 mAb combined with potent TCR stimulation may be used to block autoimmune or inflammatory diseases mediated by T cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rodentia
/
Tissue Donors
/
T-Lymphocytes
/
Cell Death
/
Receptors, Tumor Necrosis Factor
/
Graft vs Host Disease
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Immune Network
Year:
2011
Type:
Article
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