Comparison of Invariant NKT Cells with Conventional T Cells by Using Gene Set Enrichment Analysis (GSEA)
Immune Network
;
: 406-411, 2011.
Article
in English
| WPRIM
| ID: wpr-60132
ABSTRACT
BACKGROUND:
Invariant Natural killer T (iNKT) cells, a distinct subset of CD1d-restricted T cells with invariant Valphabeta TCR, functionally bridge innate and adaptive immunity. While iNKT cells share features with conventional T cells in some functional aspects, they simultaneously produce large amount of Th1 and Th2 cytokines upon T-cell receptor (TCR) ligation. However, gene expression pattern in two types of cells has not been well characterized.METHODS:
we performed comparative microarray analyses of gene expression in murine iNKT cells and conventional CD4+CD25-gammadeltaTCR- T cells by using Gene Set Enrichment Analysis (GSEA) method.RESULTS:
Here, we describe profound differences in gene expression pattern between iNKT cells and conventional CD4+CD25-gammadeltaTCR- T cells.CONCLUSION:
Our results provide new insights into the functional competence of iNKT cells and a better understanding of their various roles during immune responses.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
Gene Expression
/
Cytokines
/
Mental Competency
/
Natural Killer T-Cells
/
Adaptive Immunity
/
Ligation
Language:
English
Journal:
Immune Network
Year:
2011
Type:
Article
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