The effect of general anesthesia combined with epidural anesthesia on postoperative cognitive function in elderly colon cancer patient underwent laparoscopic radical operation / 重庆医学

ABSTRACT

Objective To observe the effect of general anesthesia combined with epidural anesthesia on postoperative cogni‐tive dysfunction(POCD) in elderly colon cancer patient underwent laparoscopic radical operation .Methods 60 cases of elderly pa‐tients underwent laparoscopic radical colon cancer operation were sellected in Qionghai People′s Hospital of Hainan Province .The patients were divided intogeneral anesthesia control group(n=30)and general anesthesia combined with epidural anesthesia obser‐vation group (n=30) .The cognitive function was estimated by MMSE .The expression of S‐100βprotein was determined by ELISA analysis .Results The recovery time of respiratory depression ,drowsiness and extubation and remifentanil dosage was no no signifi‐cant differences between the two groups(P>0 .05) .The propofol dosage and rate of nausea and vomitting was lower in observation group than that in control group(P0 .05) .MMSE value was decrease after operation for 1 and 3 d(P0 .05) .The S‐100βexpression was increase after operation for 1 and 3 d(P<0 .05) .However ,the S‐100βexpression was lower in observation group than that in control group (P<0 .05) .Conclusion The general anesthesia combined with epidural anesthesia can decrease POCD in elderly colon cancer patient underwent laparoscopic radical operation ,with worthy of clinical application .