Effects of Simvastain on Expression of Inflammatory Cytokines and Ventricular Remodeling in Rats with Acute Myocardial Infarction / 天津医药
Tianjin Medical Journal
;
(12): 585-588,后插5, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-601761
ABSTRACT
Objective:
To investigate the association between inflammatory cytokines and ventricular remodeling after acute myocardial infarction (AMI) in rats, and the effects of simvastain on inflammatory cytokines and ventricular remodeling after AMI thereof.Methods:
After AMI was produced in female SD rats, the animals were divided into control group,simvastain group and sham-operated group. After transthoracic echocardiography, TNF-α, IL-6 and P Ⅲ NP of the serum and cardiac muscle were measured by radioimmunology technology. The comparative heart weight and infarct sizes were calculated.Results:
Compared with the control group, the LVDd and LVDs decreased significantly (P < 0.05), LVEF,LVFS and posterior wall thicking increased significantly (P < 0.05) in simvastain group. The values of TNF-α, IL-6 and P Ⅲ NP increased significantly in simvastain and control group compared with those of sham-operated group(P < 0.05 or P < 0.01 ). The values ot TNF-α, IL-6 and pⅢ NP decreased significantly in simvastain group compared with those of the control group (P < 0.05). The comparative heart weight and infarct size decreased significantly in simvastain group compared with those of the control group (P < 0.05).Conclusion:
Simvastain can ameliorate the ventricular remodeling and improve cardiac performance after AMI by restraining the overexpression of inflammatory cytokines.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tianjin Medical Journal
Year:
2009
Type:
Article
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