The application value of combined detection of serum tumor markers in the diagnosis of lung cancer / 国际检验医学杂志

ABSTRACT

Objective To explore the application value of combined detection of serum carcinoembryonic antigen(CEA),carbo-hydrate antigen 1 53(CA1 53),carbohydrate antigen 125(CA125)and carbohydrate antigen 1 99(CA1 99)in the diagnosis of lung canc-er.Methods The direct chemiluminescence assay was used to detect the expression levels of serum CEA,CA1 53,CA125 and CA1 99 in 128 cases of patients with lung cancer,84 cases of patients with lung benign disease and 30 cases of healthy individuals. Results The expression levels of serum CEA,CA1 53,CA125,CA1 99 in the lung cancer group was significantly higher than those in the lung benign disease group and the healthy control group(P <0.05).The sensitivity and specificity of serum CEA was high in the lung cancer group,which was 5 1.56% and 92.1 1%,respectively.The optimized group of combined detection was CEA +CA125+CA1 99 and CEA+CA125,and the sensitivity was 75.00% and 64.84%,respectively.Conclusion Single tumor markers have certain auxiliary value in diagnosing lung cancer.Combined detection could increase diagnostic sensitivity and accuracy for lung cancer,but its specificity may decrease accordingly,so clinical diagnosis should pay attention to whether there is the occurrence of false-positive.The combined detection of serum CEA,CA125 and CA1 99 could improve diagnostic sensitivity of lung cancer.