Analysis of the risk factors of central nervous system complications after allogeneic hematopoictic stem cell transplantation / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 671-673,677, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-601977
ABSTRACT
Objective To analyse the etiology,clinical characteristics and risk factors of central nervous system (CNS) complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods The clinical features of CNS complications in patients who underwent allo-HSCT were observed,and analysis its causes and risk factors.Results 8 cases of CNS complications occured in 69 patients within 6 months after allo-HSCT and the incidence was 11.6 %,the occurrence rate of CNS complications was 21.4 % (6/28) in HLA mismatched group,higher than HLA matehed group [49 % (2/41)] (P < 0.05).Analogously,the incidence was 44.4 % (4/60) in patients with graft-versus-host disease (GVIID) (>grade 2),which was significantly higher than patients with 2 or below grade 2 GVHD [6.7 % (4/9)] (P < 0.01).But there was no significant difference in the incidence of CNS complications between ≤14 years old and >14 years old,with or without ATG,different stages of diseases,whether pretreatment with maryland respectively (P >0.05),either.Epilepsy and intracranial infection were the most common CNS complications in allo-HSCT,followed by intracranial hemorrhage.Conclusion HLA mismatched and above grade 2 GVHD are the risk factors of CNS complications in allo-HSCT.Epilepsy,intracranial infection and bleeding are common CNS complications in allo-HSCT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Risk factors
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2012
Type:
Article
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