Test analysis on homocysteine and blood coagulation fibrinolysis of patients with acute cerebral infarction / 国际检验医学杂志

ABSTRACT

Objective To analyze homocysteine in patients with acute cerebral infarction and related indicators of coagulation and fibrinolysis,diagnosis and treatment of acute cerebral infarction in order to provide reference for the disease.Methods Paitents with acute cerebral infarction from April 2012 to June 2014 were selected,they were divided into acute cerebral infarction groups and non acute cerebral infarction,,The acute cerebral infarction patients and non-patients with acute cerebral infarction group 1 ∶1.homo-cysteine and related indicators of coagulation and fibrinolysis were compared between two groups.Results Non-acute cerebral in-farction group homocysteine(Hcy),D-dimer,tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor-1 (PAI-1 ) levels were significantly lower than in acute cerebral infarction group;non-acute cerebral infarction group(INR),significantly higher than the acute cerebral infarction group,the difference was statistically significant(P <0.05);after treatment of acute cerebral in-farction group,progress group Hcy,D-dimer,t-PA,PAI-1 was significantly higher than non-progression group;progressive group of international normalized ratio (INR),activated partial thromboplastin time(APTT)was significantly lower than non-progressive group,the difference there was statistically significant(P < 0.05 );good prognosis group D-dimer,t-PA,PAI-1 were significantly lower than a poor prognosis group,the difference was statistically significant(P <0.05)Conclusion Detection Hcy and related indi-cators of coagulation and fibrinolysis can effectively determine the content of the disease in patients with acute cerebral infarction, prognosis and progress,prognosis D-dimer and patients.